Detective Murdoch finds that the man behind a flying machine that crashes in Toronto is none other than his old nemesis, James Pendrick. He learns that Pendrick is hoping to win a $1 million prize for the first controlled flight. A body is found in the rubble of the crash but someone is clearly out to steal his invention. Murdoch also has to deal with Ottawa-based spymaster Terence Meyers who says it's all a national security matter. Meanwhile, Julia returns from Vienna intent on practicing psychiatry. She's also hoping to have her marriage to D'Arcy annulled.

Murdoch and Inspector Brackenreid are aboard the SS Keewatin after the owner, Clarence MacFarlane, receives what he believes is a threat. The Keewatin is about to depart from Toronto on its maiden voyage destined for Rochester, N.Y. and Murdoch thinks they should stay on board, especially after he sees that Julia is one of the invited guests. Their presence proves useful after MacFarlane's daughter Amy, who is engaged to her father's chief financial officer Owen Mathers, falls overboard and is nowhere to be found. As Murdoch investigates he finds there is a real threat against the Keewatin and the true facts behind Amy's disappearance.

Six months have passed since Dr. Ogden moved to Buffalo and Det. Murdoch is constantly a loggerheads with Dr. Francis, her replacement. While Insp. Brackenreid thinks highly of Francis, who was recruited from Scotland Yard, Murdoch finds him stubborn and unimaginative. He also seems to be in no rush to help Murdoch with his latest case where human body body parts were discovered on a riverbank encased in cement. A homeless man living in the woods nearby is questioned and released and Murdoch corresponds with Dr. Ogden who offers him valuable advice in her letters. He also gets help from a retired detective, Malcolm Lamb. Murdoch connects his current investigation a rape and murder that had occurred many years before.

一对老夫妻为了复活自己的外孙，于是绑架孕妇，尝试执行恶魔仪式，让孙子通过孕妇未出世的孩子复活，结果随着警察的调查和超自然事件的发生，导致事情逐渐失去老夫妻的控制。

故事描述一名开音像店的亿万富翁Johnny Rose（Eugene Levy）和他的肥皂剧明星妻子Moira（Catherine O’Hara）、嬉皮士儿子David（Daniel Levy）、交际花女儿Alexis（Annie meijubar.net Murphy）在一夜之间破产。这家人不得不离开已经习惯了的奢华生活，回到乡下去「从零开始」。好在他们还有一点私人领地：当年他们抱着好玩的心态在最偏僻的角落里买下一座几乎没有人烟的小镇（镇名即本剧标题「施米特湾」），现在这里成了他们仅存的落脚点。他们必须尽快适应新的贫穷生活，找到家庭的真谛……但这个穷乡僻壤的地方让他们感觉「限制」太多！

Season five of Murdoch Mysteries opens in unfamiliar territory, as Detective William Murdoch (Yannick Bisson) leaves Toronto to try his luck while the Klondike Gold Rush in the Yukon winds down. Suspended for interfering in an investigation, on the run for surreptitiously freeing a murderer to make amends, and nursing a broken heart after Dr. Ogden's marriage to another man, he tries to escape his past, and his passion for detective work. Back in the city, newly promoted Chief Constable Giles (Nigel Bennett) makes it clear to Inspector Thomas Brackenreid (Thomas Craig), that he'll be keeping a very close eye on police matters. Meanwhile, Murdoch's beloved former associate, Dr. Julia Ogden (Hélène Joy), is now working alongside Acting Detective George Crabtree (Jonny Harris) and Dr. Emily Grace (Georgina Reilly), a feisty young protégé. In the remote north, Murdoch is pleased to discover that his fledgling prospecting career may garner great success, a small comfort after Julia's marriage to another man. But as he tries to rebuild his life, he finds himself drawn into the case of Mrs. Elizabeth Bryant (Jill Halfpenny), an innkeeper charged with murder. The plot thickens when writer Jack London (Aaron Ashmore) lends his insights, and Murdoch soon realizes that while he had hoped to leave his shattered heart and tattered career back in Toronto, his days as a detective are not behind him.