After a governor issues an executive order to arrest the children of undocumented immigrants, the newly detained youth are offered an opportunity to have their charges dropped by volunteering to provide care to the elderly. Once inside the eldercare facility, the volunteers discover the governor and the facility’s supervisor have cooked up a horrifyingly depraved conspiracy that endangers both the young and the old…

Will, a young Hispanic gay potter, is one gregarious guy. His boss is terrible, but he's got a great boyfriend and a great job. Unfortunately, behind that veneer is a dark past of violence and mental illness that he is desperate to keep hidden. When his bipolar mother comes out of the woodwork after ten years of silence, he begins exhibiting unexplainable symptoms. After an injury at work, he starts losing functioning of his arms, and something sinister lurks in the corner of his vision: a silent and ominous man in a wolf costume. Will spirals into an obsession, determined to solve this mystery of his own. What is going on with his arms? Can he trust his boyfriend? Is he becoming his mother?

电影讲述了漫威漫画中最神秘的女超级英雄的起源故事。急救护工凯茜（蜘蛛夫人，达科塔·约翰逊 Dakota Johnson 饰）因一场意外发现自己能够预知未来，在探寻能力起源的过程中，她与三位蜘蛛女的命运紧密联结在一起。面对反派“毒蜘蛛”以西结的追杀，蜘蛛夫人试图找明原因。穿梭在时间线中的她们将如何利用预知未来的能力改变世界命运？