洛杉矶又受到怪物的袭击，这次袭击的怪物力量远比它们的前辈更为强大，整座城市陷入了恐慌之中，罗素博士临危受死,带领着冲锋队奋起迎战。

一个隐蔽的海洛因治疗中心的病人和工作人员必须与他们自己的恶魔进行战斗，因为一个神秘的杀手开始一个接一个地把他们抓走。

Scientists make a horrible discovery: The "Big One" is coming in two days, with it, California will sink to the ocean. Their only hope is to rupture a volcano that will displace the earthquake's energy and build a new crust on the surface. But as foreshocks turn California into chaos, it's a race against time the scientists might not win.