安妮•布外兹（Tisa Farrow 饰）的父亲驾船前往某小岛，但此后三个月音讯全无。某日，父亲的小船漂回纽约，船上空无一人。当警卫员检查船舱时，却遭到一个丧尸的袭击。记者彼得•怀斯特（Ian McCulloch 饰）对此事颇为好奇，他和安妮相约前往那座神秘小岛。 当他们到达目的地时，却惊奇地发现，当地伏都教的诅咒令人们染上一种怪病，且可使死人复活。但复活后的人只是嗜血如命的恐怖丧尸。他们在岛上遇见了莫纳德医生（Richard Johnson 饰），为了活命，三个人必须通力合作，找到治疗这种怪病的方法……

Milan, 2030; where only eight years earlier the independent global spy agency Citadel was wiped out by Manticore, the powerful enemy syndicate that manipulates the world from the shadows. Since then, Diana Cavalieri (who is an undercover Citadel agent) is alone, trapped behind enemy lines as a mole in Manticore. When Diana finally sees a way out and the chance to disappear forever, her only option is to trust the most unexpected ally, Edo Zani, heir of Manticore Italy, son to the head of the evil syndicate's Italian unit; who just so happens to be vying for Manticore's leadership against other European families.