安妮•布外兹（Tisa Farrow 饰）的父亲驾船前往某小岛，但此后三个月音讯全无。某日，父亲的小船漂回纽约，船上空无一人。当警卫员检查船舱时，却遭到一个丧尸的袭击。记者彼得•怀斯特（Ian McCulloch 饰）对此事颇为好奇，他和安妮相约前往那座神秘小岛。 当他们到达目的地时，却惊奇地发现，当地伏都教的诅咒令人们染上一种怪病，且可使死人复活。但复活后的人只是嗜血如命的恐怖丧尸。他们在岛上遇见了莫纳德医生（Richard Johnson 饰），为了活命，三个人必须通力合作，找到治疗这种怪病的方法……

Angela deMarco is unhappily married to high Mafia member Frank deMarco. When Frank is killed, Angela takes the opportunity to break free of the Mafia world entirely and start a new life. But Frank's boss, Tony Russo, begins to court the unresponsive Angela. The FBI begins surveillance on her, thinking her to be his new mistress. FBI agent Mike Downey goes undercover as Angela's neighbor, but soon finds himself attracted to Angela himself.